It should be pointed out LCN2 expression has been shown to elevate the aggressiveness of breast (Yang et al., 2009), melanoma (Adler et al., 2023), and colon cancers (Chaudhary et al., 2021), suggesting that WT bacteria may show reduced anticancer activity in more aggressive cancer types due to higher iron competition. Here, LCN2 is linked to malignant colon neoplasm.