PKP2 and Arrhythmogenic right ventricular dysplasia: Among the pathogenic variants, mutations on plakophilin 2 (PKP2) are reported to account for 20%–46% of ARVC cases, whereas desmoplakin and desmoglein 2 (DSG2) account for 10% each, desmocollin 2 for 5%, and plakoglobin for less than 1% (1–4).