Previous studies revealed that Dsg2-mutant (Dsg2mut/mut) mice have characteristics that resemble clinical features of patients with ACM, including fibrofatty replacement, contractile dysfunction, ventricular arrhythmias (i.e., premature ventricular contractions [PVC] and ventricular tachycardia [VT]), exacerbated phenotype with exercise, and inflammation (11–14). Here, DSG2 is linked to Ventricular arrhythmia.