In the full model with each of the genes analyzed individually, adjusting for age, sex, race and ethnicity, cigarette smoking, physical activity level, BMI, triglycerides, systolic blood pressure, and plasma HDL-cholesterol (HDL-C), risk for prediabetes/T2D was higher among MESA participants in the lowest tertile of expression of 3 coexpressed LXR target genes (10–12) — ABCG1, ABCA1, and MYLIP (pairwise correlation between expression of the 3 genes ranges from 0.47 to 0.71; Supplemental Table 2). This evidence concerns the gene ABCG1 and type 2 diabetes mellitus.