The risk of prediabetes/T2D for overweight/obese individuals was highest when they also had lower levels of ABCG1 expression compared with normal-weight individuals with the third tertile of ABCG1 expression (HR for individuals with the first tertile of ABCG1 expression and overweight: 3.83 P = 0.0002; or obesity: 3.12, P = 0.003). This evidence concerns the gene ABCG1 and type 2 diabetes mellitus.