In the community-based MESA cohort free from prediabetes or T2D at baseline, we identified that expression of 3 LXR target genes, ABCG1 and ABCA1 (cholesterol efflux genes) and MYLIP (cholesterol uptake suppression gene), was inversely associated with incident prediabetes/T2D, independent of traditional risk factors. Here, ABCG1 is linked to type 2 diabetes mellitus.