Because Piezo1, genes of the ANGPT/TIE pathway, and Foxo1 have all been shown to modulate lymphatic valve development and function in mice, and mutations in PIEZO1, ANGPT2, and TIE1 have been identified in patients with lymphedema, we suspected they might be related in a common network, leading us to explore possible interactions (4, 30, 34). The gene discussed is FOXO1; the disease is lymphedema.