Moreover, noncanonical WNT ligands such as WNT10B or WNT3A did not induce the expression of WNT5A in cultured human or murine fibroblasts (Supplemental Figure 3, F and G), demonstrating that the upregulation of WNT5A is not a consequence of activated WNT/β-catenin signaling in SSc. The gene discussed is WNT3A; the disease is systemic sclerosis.