Profiling of all known WNT proteins that are capable of activating noncanonical WNT signaling pathways (28) identified WNT5A as the ligand with the highest mRNA levels and the most pronounced upregulation in skin samples of patients with SSc compared with people in a healthy control group (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI159884DS1). Here, WNT5A is linked to systemic sclerosis.