WNT5A and systemic sclerosis: Comparison of the lists of genes regulated by WNT5A in dermal fibroblasts with genes deregulated in the skin of patients with SSc revealed that 38% of all DEGs in skin biopsies of a cohort of patients with early, diffuse-cutaneous SSc (PRESS cohort) (29) matched the genes regulated by WNT5A in cultured fibroblasts (Figure 2D).