Moreover, noncanonical WNT ligands such as WNT10B or WNT3A did not induce the expression of WNT5A in cultured human or murine fibroblasts (Supplemental Figure 3, F and G), demonstrating that the upregulation of WNT5A is not a consequence of activated WNT/β-catenin signaling in SSc. Here, WNT5A is linked to systemic sclerosis.