FDX1 and atherosclerosis: Key mitochondrial complexes involved in respiration are regulated by FDX1-mediated lipoylation, and FDX1 deficiency results in loss of respiration.80 A genome-wide CRISPR screen demonstrated that it was essential for oxidative phosphorylation.81 While mitochondrial dysfunction is recognized as a contributory mechanism in the initiation of atherosclerosis,82 the role of ferredoxin has not been characterized in the context of coronary artery disease.