MITF is a key TF influencing lysosome function and autophagy.66,67 An intronic variant rs12714757 has been associated with CAD risk in both European and East Asian populations (β=0.033 and 0.048, respectively).18,68 In our analysis, 2 closely linked SNPs rs6772383 and rs11452399 overlapped an intronic CRE of MITF (Figure 6A). Here, TF is linked to coronary artery disorder.