Since, the status and role of 5-Lox pathway and its downstream mechanisms in the pathobiology of pancreatic cancer is still unknown, systematic exploration of the involvement of, (1) the phosphatidylinositol 3’-kinase-Akt/protein kinase B (PI3K-Akt) pathway, and (2) the protein kinase C-epsilon (PKCε) pathway is needed. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.