These findings suggest that pancreatic cancer cells gain survival and growth advantages from the readily available arachidonic acid (abundant in high-fat “Western” diets) via generation of 5-Lox metabolites and that the survival-promoting effect of 5-Lox is exerted via downstream signaling involving the serine/threonine protein kinase, PKCε. Here, PRKCE is linked to pancreatic neoplasm.