CGAS and Miyoshi myopathy: Moreover, Dox treatment generally increased the expression and protein levels of cGAS in SKO-007(J3), ARK, ARH-77 and, albeit much more variably, in primary malignant plasma cells (PCs) from a fraction of MM patients at disease onset (Table 1), as measured by real-time PCR and western blot analysis (Figures 1E–1H), indicating that Dox can amplify the production and release of cGAMP by triggering a stress response that regulates the amount of cGAS protein at transcriptional level.