Several recent studies have identified the recurrent rearrangement of the VGLL2 and TEAD1 genes in a large subset of spindle cell rhabdomyosarcoma (scRMS), a pediatric form of RMS that is distinct from embryonic RMS (ERMS) (Alaggio et al., 2016; Tan et al., 2020; Chen et al., 2020; Cyrta et al., 2021; Whittle et al., 2022). The gene discussed is VGLL2; the disease is spindle cell rhabdomyosarcoma.