To study interactions among circadian clock genes and cell survival, and their role in BD and predicting lithium response, we tested selected genes (<i>PER1</i>, <i>BMAL1</i> and <i>REV-ERBα</i>) and small molecule modulators of ROR/REV-ERB nuclear receptors in models of cell survival using mouse neurons and stem-cell derived neuronal progenitor cells (NPC) from BD patients and controls. This evidence concerns the gene PER1 and Behcet disease.