GBP5 and COVID-19: Intriguingly, analysis of scRNA-seq datasets from SARS-CoV-2-susceptible upper airway cells revealed higher expression of GBP5 in cells from healthy children vs healthy adults, and a larger induction of GBP5 in cells from SARS-CoV-2-infected children vs infected adults (Fig 1d and S1f), which is consistent with the recent suggestion that higher basal activity of the innate immune system in children may explain their lower SARS-CoV-2 infection rate and decreased risk of developing COVID-19 compared with adults10.