GBP genes were also upregulated in SARS-CoV-2 infected human alveolar epithelial type-2 (AT2) organoids and lung tissues from COVID-19 patients, with GBP5 being highly upregulated in both cases (~44-fold and ~16-fold vs mock-infected cells and normal lung tissue, respectively; Fig 1b,c)27,28. Here, GBP5 is linked to COVID-19.