Specifically, FTO is targeted by bisantrene for acute myeloid leukemia (Phase II), and GRM2 is targeted by four investigational drugs for central nervous system disorders including schizophrenia, major depressive disorder, perceptual disorders, bipolar disorder, psychosis, methamphetamine dependence, post-traumatic stress disorder, and seizure disorder. The gene discussed is GRM2; the disease is major depressive disorder.