SLAMF7 and neoplasm: We observed superior binding of BCMA and SLAMF7 to the Bi-ChTCR compared to the BCMA/SLAMF7 CAR (Extended Data Fig. 9a-c), and T cells expressing Bi-ChTCR exhibited more rapid and intense Zap70 phosphorylation than bispecific CAR T cells after stimulation with bead-coated BCMA and SLAMF7 alone, or together (Extended Data Fig. 9d,e). We then asked whether BCMA/SLAMF7 Bi-ChTCR+ T cells could eliminate a tumor inoculum comprised of Nalm-6 cells that were heterogeneous for BCMA and SLAMF7 expression in NSG mice (Fig. 6j).