For example, miR-181b affects the expression of miR-21 through the TF FOS, a critical signaling protein for glioma progression (Tao et al., 2013); miR-660-5p controls the expression of miR-486-5p via mouse double minute 2 (MDM2) and p53 (also known as TP53) in a study of lung cancer (Borzi et al., 2017). This evidence concerns the gene TP53 and central nervous system cancer.