In a murine model of septic liver injury, sophocarpine effectively suppressed the p38/JNK signaling pathway, mitigated oxidative stress, and upregulated the expression of anti-inflammatory factors such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) to exert hepatoprotective effects (Zhengyu et al., 2018). Here, MAPK8 is linked to injury.