They found that sophocarpine regulated blood glucose, insulin, LDL-c content and HDL-c levels while concurrently mitigating pancreatic injury and effectively impeding the advancement of type 2 diabetes by attenuating peroxisome proliferator-activated receptor gamma (PPARγ) activity in mice with type 2 diabetes (Su et al., 2021). This evidence concerns the gene PPARG and type 2 diabetes mellitus.