In a rat model of 2,4,6-trinitrobenzene sulfonic acid-induced colitis, the total alkaloid Sophora alopecuroides (TASA), whose main ingredient is sophocarpine, was found to exert a strong anti-inflammatory effect by upregulating the levels of CD4+CD25+ Tregs and IL-10 in the colon and peripheral blood (Zhou et al., 2010a). The gene discussed is CD4; the disease is colitis.