Similarly, Wu et al. have reported that sophocarpine can also attenuate inflammatory factors such as IL-6 and TNF-α in both in vivo and in vitro models of osteoarthritis-related inflammatory cartilage degeneration, with mechanisms involving the PI3K/AKT and NF-κB signaling pathways (Wu et al., 2019). Here, AKT1 is linked to osteoarthritis.