Wang et al. used a comprehensive 2D PC-3 cell membrane chromatography (CMC) system to identify anti-prostate cancer components, including sophocarpine, and found that sophocarpine effectively inhibited epidermal growth factor-induced prostate cancer (PC-3) cell proliferation and induced apoptosis in a dose-dependent manner (Wang et al., 2017). This evidence concerns the gene EGF and Familial prostate cancer.