Univariate regression analysis revealed that age (1.075 [1.036–1.115], P<0.001); duration of hypertension (1.069 [1.025–1.115], P<0.05); tumor size (3.921 [2.180–7.054], P<0.001); ACTH (0.971 [0.945–0.998], P<0.05); and DHEAS (0.995 [0.991–0.999], P<0.05) were significantly associated with UPA with 1-mg DST>1.8 ug/dL. The gene discussed is SULT2A1; the disease is hypertensive disorder.