IL2RA and osteonecrosis: IL-2RA has been shown to be associated with the development of autoimmune inflammatory diseases (41, 42), and immune disorders affecting the skeleton may be an important cause of osteonecrosis, with a strong association between abnormal immune responses and immune cell infiltration in osteonecrosis tissue, often resulting in necrotic bone tissue showing signs of uncontrolled inflammation (43, 44).