Furthermore, in drug-induced osteonecrosis, a higher genetic prediction level of cyclic SCF was associated with an elevated risk of osteonecrosis according to the IVW approach (OR=3.356, 95% CI=1.09-10.30, P=0.034 per 1 standard deviation (SD)) (Supplementary Figure 2). Here, KITLG is linked to osteonecrosis.