Furthermore, heightened IL-2RA levels were associated with an elevated risk of osteonecrosis (OR=1.386, 95% CI=1.04-1.85, p=0.026), while increased IL-2 levels were linked to a decreased risk (OR=0.688, 95% CI=0.50-0.94, p=0.021, per 1 standard deviation (SD) increase). The gene discussed is IL2; the disease is osteonecrosis.