Notably, bFGF with genetically predicted levels of IL-2RA exhibited a positive, though not statistically significant, causal effect on drug-induced osteonecrosis (OR=2.324, 95% CI=0.62-8.72, p=0.211 per 1 standard deviation (SD); OR=1.053, 95% CI=0.51-2.19, per 1 standard deviation (SD) P=0.888). The gene discussed is FGF2; the disease is osteonecrosis.