Phenotypically, Pin1 overexpression transforms regular mammary epithelial cells into stem-like tumor cells with enhanced tumorigenicity, whereas Pin1 inhibition or knockdown significantly impairs breast CSC expansion, mesenchymal marker expression, tumor initiation, self-renewal potential, and metastasis (Ryo et al., 2001; Zhang et al., 2008; Kim et al., 2009; Ikushima et al., 2011; Tong and Jiang, 2015; Xiao et al., 2017; Chen et al., 2019; Celià-Terrassa and Jolly, 2020; Sui et al., 2020). Here, PIN1 is linked to neoplasm.