However, the inhibition of Notch1 signaling with the Notch1/2 small-molecule inhibitor MRK-003 or its endogenous inhibitor Numb decreased RCC stem-like characteristics such as self-renewal, chemoresistance, tumorigenesis, and migratory potential (Xiao et al., 2017). Here, NOTCH1 is linked to renal cell carcinoma.