KPT-6566 is a covalent Pin1 inhibitor that modifies C113 with the addition of a sulfanyl-acetate group via a disulfide bond; this reaction releases a quinone-mimicking drug that generates reactive oxygen species (ROS) and damages DNA, further contributing to Pin1-mediated cell death in cancer cells (Campaner et al., 2017). The gene discussed is PIN1; the disease is cancer.