The organoids with clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) which incorporate common genetic alterations [Kras or B-Raf proto-oncogene (BRAF)] revealed a specific tumor niche and prognostic gene markers representing human serrated CRC [74, 153]. The gene discussed is BRAF; the disease is colorectal carcinoma.