The Kinase-Signaling cluster, fundamental in manipulating cellular signaling pathways like rat sarcoma virus (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated extracellular signal-regulated kinase (MEK)/ERK and mechanistic target of rapamycin (mTOR), experiences disruptions due to genetic defects, upsetting cellular proliferation, differentiation, and apoptosis equilibriums [51, 52]. The gene discussed is MTOR; the disease is fibrosarcoma.