The type 1 immune cytokine IFNγ promotes macrophage polarisation towards the anti-tumour proinflammatory IL-12-producing phenotype [44, 45], while stimulation by the type 2 cytokines IL-4 and IL-13 results in polarisation towards the tumour-promoting alternatively activated phenotype [46, 47]. The gene discussed is IFNG; the disease is neoplasm.