KLRB1 and neoplasm: Single-cell RNA sequencing (scRNAseq) of human patient tumour samples revealed that these GzmA-expressing cells consist of two clusters of ILCs and were defined by high expression of the killer cell lectin-like receptor B1 (KLRB1) gene (which encodes for CD161), a marker known to characterise functional, proinflammatory NK cells that are responsive to innate immune cytokines [85].