This contrast is likely related to the lack of IL-23 expression by adenocarcinoma cells while, tumour cells from SqCCs produced IL-23 that promoted the conversion of ILC1s to ILC3s which produced IL-17, the latter capable of facilitating the recruitment of myeloid-derived suppressor cells (MDSC) and tumour-associated neutrophils (TANs) to the TME [112, 113] and inhibiting the CD8+ T cell response [114]. This evidence concerns the gene CD8A and neoplasm.