Intriguingly, comparison of chromophobe renal cell carcinoma (RCC; chRCC) to clear cell RCC (ccRCC) in human patients revealed that chRCC tumours express higher levels of IL-15, and this is reflected by the higher expression of GzmA in ILC1s compared to NK cells in chRCC, while the opposite is observed in ccRCC which express minimal levels of IL-15 [78]. The gene discussed is GZMA; the disease is chromophobe renal cell carcinoma.