APOB and hypertensive disorder: To investigate the potential mediation of six lipid profiles (LDL, HDL, TC, TG, Apo-A, Apo-B) and five liver function indices (ALT, AST, ALP, γ-GGT, Bile acid) in the relationship between ICP and CVD, CAD, and HTN, a two-step MR analysis was employed (Figure 2).