This mediational MR analysis revealed that LDL, TC, and Apo-B predominantly mediate the indirect impact of ICP on CVD, aligning with the meta-analysis findings of Zhan Y et al. Zhang's research further indicated that severe maternal dyslipidemia was more common in the severe ICP cohort, hinting at a potential link between the severity of ICP and dyslipidemia (36). The gene discussed is APOB; the disease is metabolic syndrome.