PDGFB and aortic aneurysm: Saito et al. inhibited NF-κB signaling in VECs and noted a substantial downregulation of the expression of SMC proliferation-related cytokines such as platelet derived growth factor subunit B (PDGF-B), ICAM-1 and VCAM-1, which subsequently suppressed macrophage-associated inflammation and OS, thereby inhibiting the generation of aortic aneurysms (76).