LRG1 and choroidal neovascularization: This study went on to show that the Lrg1 transcript is almost undetectable in the healthy mouse retina but in experimental retinal vascular diseases such as experimental choroidal neovascularization (CNV) (113) and oxygen-induced retinopathy (OIR) (114) that model choroidal and retinal neovascularization respectively, expression of LRG1 is induced in endothelial cells (25).