One of the most compelling pieces of clinical evidence that LRG1 contributes to DKD, however, was a recently reported GWAS study in people with type 2 diabetes and CKD, where a 5'UTR variant (rs4806985) in the promoter region of LRG1 was found to influence its gene expression resulting in elevated plasma LRG1 and a robust association with increased risk of rapid decline in kidney function (51). This evidence concerns the gene LRG1 and diabetic kidney disease.