For instance, single cell RNA sequencing revealed Lrg1 as one of the most upregulated genes in disease-associated endothelial cells in murine models of liver cancer (96) and atherosclerosis (97), while a seminal study demonstrated that LRG1 originating from endothelial cells contributes primarily, in an autocrine fashion, to vessel malfunction and disease severity in a model of emphysema (37). Here, LRG1 is linked to atherosclerosis.