In various other in vivo models of CKD, including the albumin overload model (136), unilateral ureteral obstruction (UUO) model (34), and the aristolochic acid-induced nephrotoxicity (AAN) model (33), LRG1 protein levels have also been shown to be higher, often correlating with increased pro-inflammatory and pro-fibrotic cytokines. Here, LRG1 is linked to chronic kidney disease.