This is in accordance with other findings showing that LRG1 promotes fibrosis in various tissues and conditions including the skin (41), idiopathic pulmonary fibrosis (42), renal fibrosis (34) as well as diabetic nephropathy (33, 121), by directly affecting the physiology and activity of fibroblast-like tissue resident cells (Figure 1). Here, LRG1 is linked to diabetic kidney disease.