LRG1 and diabetic retinopathy: In diabetic retinopathy, where retinal vascular dysfunction, dropout and neovascularization are prominent, LRG1 has been reported to be upregulated not only in the vitreous humour and in ocular tissues (25, 50, 125, 126), but also systemically in the plasma of patients with proliferative diabetic retinopathy (PDR) (50, 127).