Notably, in Parkinson's disease (PD), the deacetylation of succinate dehydrogenase complex, subunit A (SDHA), mediated by SIRT3, activates mitochondrial complex II, suggesting a critical role for the SIRT3-SDHA axis in promoting metabolic efficacy and neuroprotection (Shen et al., 2023). Here, SDHA is linked to Parkinson disease.