MAPT and neurodevelopmental disorder: Excessive phosphorylation or acetylation of Mapt has been associated with neurotoxicity and is believed to potentially contribute to neurodevelopmental disorders in infants (Sarnat and Flores-Sarnat, 2015), and has been strongly linked to neurodegenerative disorders (Zhang et al., 2016; Toker et al., 2021; Ruiz-Gabarre et al., 2022).