Rohban et al. used this approach to reveal a previously unknown interaction between the NF-κB pathway and Hippo pathways, which regulate tumorigenesis and tumor progression103, and furthermore to identify promising compounds that match a desired phenotypic profile impinging on those pathways.104 Disease-specific morphological signatures can serve as biomarkers for disease diagnosis or prognosis, or to monitor therapeutic responses. This evidence concerns the gene NFKB1 and neoplasm.