It was also used to explore novel therapies for ER stress-associated disorders by identifying compounds that corrected aberrant morphological phenotypes associated with ER stress.107 Cell Painting has also been used to investigate transcription factor EB (TFEB) signaling and lysosomal dysfunction by detecting phenotypic changes in organelles in response to TFEB localization.108 Finally, the assay was also used to investigate drug resistance in anti-cancer therapy109 by identifying the morphological signature of bortezomib treatment resistance in cells. The gene discussed is TFEB; the disease is cancer.