CXCR4 and acute respiratory distress syndrome: When the MIF pathway was present in the pulmonary ALI group, a shift of the main signal emitter to Treg cells could be noticed, the intensity of the DC, the receiver of the signal, did not change, but the signal received by the B cells was significantly enhanced, and the neutrophils no longer received the signal from MIF (Figures 6E-G).Mif-(Cd74+Cd44) and Mif-(Cd74+ Cxcr4) signal intensities in the pathway did not change significantly, but Mif-(Cd74+Cxcr2) ceased to play a role (Figure 6H).