These patients’ clinical phenotypes were also different from a typical spectrum of anti-NMDAR encephalitis: multifocal demyelinating syndrome (#1, later diagnosed with multiple sclerosis based on the subsequent course of the disease and the absence of GluN1-abs in the follow-up CSF), isolated seizures (#2), autoimmune post-herpes simplex encephalitis (#3), new-onset nonconvulsive status epilepticus (#4), and GlyR-ab-positive progressive encephalomyelitis with rigidity and myoclonus (#5). Here, GRIN1 is linked to encephalitis.