IL4 and Alzheimer disease: Previous studies have shown that the development of AD involves certain cytokines, which intracellularly signal through Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways, such as interkeukin (IL)-4, IL-5, IL-13, IL-22, IL-31, or thymic stromal lymphopoietin (TSLP) (3).