This hypothesis is supported by independent experiments showing that the blockade of CD200R significantly increased Mtb growth in the 3D-granuloma model; and that Mtb infection in the 3D model induces reduced gene expression of CD200R1. Therefore, these data indicate that, like T-cells, regulation of myeloid immune responses in the lung is likely to play an important part in limiting immunopathology in TB. This evidence concerns the gene CD200R1 and tuberculosis.