To further understand the pro-inflammatory impact of GzB-IL18, we co-cultured pCAR-H/T T cells and their armored derivatives with MDA-MB-468 tumor cells (Figure S3A) or anti-CD3+CD28 beads (Figure S3B) and measured tumor necrosis factor (TNF)-⍺ and IL2 in derived supernatants. The gene discussed is CD28; the disease is neoplasm.