In this study, we have focused on two processes: the physiological overriding mechanism, which reflects the shifting nature of neutrophils from cells ready to neutralise pathogens to cells reducing inflammation by initiating tissue regeneration after IL-10 exposure and the pathological mechanism disturbing this phenomenon by prolongated pre-activation observed in patients suffering from autoimmune disease and after direct activation by LPS observed during sepsis. Here, IL10 is linked to autoimmune disease.