Among these genes, we noted those that additionally correlate with the in vitro model: KDM4D (Lysine Demethylase 4D - JMJD2D) for periodontitis patients, AURKA (aurora kinase A) for NMOSD and HLTF (Helicase Like Transcription Factor) for sepsis patients (Supplementary Table 2 green font). The gene discussed is HLTF; the disease is Sepsis.