Probably, this phenomenon has severe clinical implications in the course of the second phase of sepsis, during compensatory anti-inflammatory response syndrome (CARS), as neutrophils isolated from the blood of these patients were characterised inter alia: abnormal high number immature neutrophils, delayed apoptosis and uncontrolled synthesis of pro-inflammatory factors despite of high concentration of anti-inflammatory IL-10 in serum [43, 44]. This evidence concerns the gene IL10 and Sepsis.