Thus, these results together indicated that PAX6/STAT5A axis appears to change the lineage plasticity through inhibiting the expression of methyltransferases catalyzing the trimethylation of H4K20, such as KMT5C and SMYD5, to attenuate the H4K20me3, causing the NE trans-differentiation in PCa cells (Fig. 8g). Here, PAX6 is linked to posterior cortical atrophy.