PAX6 and posterior cortical atrophy: Consistently, in human PCa cell lines, we found that the PAX6 expression was significantly upregulated in the DU145 and PC3 cells, with characteristics of prostatic small-cell/NE carcinoma [33] (Fig. 1k and Supplementary Fig. S1j), compared to that in the LNCaP cells, a well-known non-NEPC cell line [34].