ONECUT2 and posterior cortical atrophy: To screen potential candidates of NE trans-differentiation driver genes, we analyzed the expression profiling changes using data from 3 NEPC related datasets, including GSE239593 dataset (Bulk RNA-seq analysis data from a 3D-engineered PCa cell derived tissue (EPCaT) model), GSE244024 dataset (transcriptome profiling changes after over-expression of ONECUT2 (OC2) in LNCaP cells) and GSE202299 dataset (transcriptome profiling changes after knockdown of TP53 and RB1 in C42B cells) (Fig. 1a, and Supplementary Table S3).