To screen potential candidates of NE trans-differentiation driver genes, we analyzed the expression profiling changes using data from 3 NEPC related datasets, including GSE239593 dataset (Bulk RNA-seq analysis data from a 3D-engineered PCa cell derived tissue (EPCaT) model), GSE244024 dataset (transcriptome profiling changes after over-expression of ONECUT2 (OC2) in LNCaP cells) and GSE202299 dataset (transcriptome profiling changes after knockdown of TP53 and RB1 in C42B cells) (Fig. 1a, and Supplementary Table S3). Here, TP53 is linked to posterior cortical atrophy.