Thus, these results together indicated that PAX6/STAT5A axis appears to change the lineage plasticity through inhibiting the expression of methyltransferases catalyzing the trimethylation of H4K20, such as KMT5C and SMYD5, to attenuate the H4K20me3, causing the NE trans-differentiation in PCa cells (Fig. 8g). This evidence concerns the gene SMYD5 and posterior cortical atrophy.