Astaxanthin-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction and Impaired Bone Formation of glucocorticoid-Induced Osteonecrosis of The Femoral Head in RatsThe fact that we did not compare the effects of AST with those of multiple clinical medications used to treat individuals with GIONFH, however, poses a potential drawback to the research we conducted. The gene discussed is NFE2L2; the disease is osteonecrosis.