Despite having an exclusive paternal expression in mammalian tissues as an antisense RNA of the KCNQ1 domain [53], KCNQ1OT1 is programmed to control both maternal and paternal p57 alleles by interacting with the chromatin on the intragenic regions of p57 and deletion of KCNQ1OT1 causes overexpression of maternal p57 which can result in severe disabilities like the Beckwith-Wiedemann syndrome [2, 38]. The gene discussed is KCNQ1OT1; the disease is Beckwith-Wiedemann syndrome.