IHC showed that the expression of the tumor proliferation marker Ki67, the M2 polarization markers CD163 and CD206, and GAL3 in the xenograft tumor tissues was significantly increased by the OC exo treatment, but this increase was decreased in the SK OC exo group as well (Fig. 5B-D), mirroring the observations in vitro. This evidence concerns the gene CD163 and neoplasm.