Upon oxidative stress, Keap1/Nrf-2 complex dissociates which is followed by nuclear translocation of Nrf-2 and activation of transcription of various cytoprotective genes e.g. HMOX1, NQO1 and SOD1. Deregulation of p62/Keap1/Nrf-2 axis has been reported in various cancers [18–23]. Here, NFE2L2 is linked to cancer.