Adolescents with allergy history who have positive allergen-specific IgE, including rye grass [OR = 0.20, 95%CI: (0.06–0.74)], Bermuda grass [OR = 0.21, 95%CI: (0.06–0.77)], white oak [OR = 0.36, 95%CI: (0.14–0.93)] and birch tree [OR = 0.34, 95%CI: (0.13–0.92)], seemed to have lower odds of IR. Here, IGHE is linked to allergic disease.