Adolescents without history of asthma who have allergen-specific IgE including rye grass [OR = 0.34, 95%CI: (0.13–0.94)], white oak [OR = 0.40, 95%CI: (0.26–0.61)], Russian thistle [OR = 0.24, 95%CI: (0.08–0.74)], and peanut [OR = 0.15, 95%CI: (0.04–0.59)] had lower odds of IR. This evidence concerns the gene IGHE and asthma.