Moreover, the levels of inflammatory mediator expression among the localized PCa tumors from 118 neoadjuvant-naive patients who had radical prostatectomy varied greatly, according to immunohistochemistry (IHC) analyses [29]; however, the majority of samples (> 94–95%) had, IL-1, and NF-kB expression, which is a recognized modulator of inflammatory reactions. This evidence concerns the gene NFKB1 and posterior cortical atrophy.