Rapid diagnostic tests have become crucial alternative tool for malaria diagnosis even if, some RDTs are Plasmodium specific, detecting the genus-specific aldolase and the recent discovery that some P. falciparum parasites in parts of South America and Africa have deleted the hrp-2 gene [16, 17] has raised a question on the use of the HRP-2 based RDTs due to false negatives. The gene discussed is HDGFL2; the disease is malaria.