TF and chronic myelogenous leukemia, BCR-ABL1 positive: To comprehensively profile the cis regulatory elements and trans TFs across the entire human regulatory genome under native conditions, we fine-tuned the Micrococcal Nuclease digestion to relatively low degree, and performed library preparation and high-throughput sequencing (loMNase-seq) to obtain a genome-wide set of footprints protected by TF binding on native chromatin in chronic myelogenous leukemia cell line K562 (Henikoff et al, 2011; Iwafuchi-Doi et al, 2016) (Fig. EV1A).