FCGR2B and glomerulosclerosis: Next, the histological findings of the kidneys by H&E staining showed that Fcgr2b−/− mice developed fibrocellular crescent, glomerulosclerosis, and interstitial infiltration, while the treated Fcgr2b−/− mice with ISD017 and CYC had less severe disease (Fig. 2C, top row).