TLR-mediated mechanisms play roles in the MRL. Faslpr lupus-prone mice27, While the MRL. Faslpr mice develop fatal glomerulonephritis, plasmacytoid DC activation, activated T- and B- cells, and anti-dsDNA production without Tlr928; the absence of Tlr7 reduces the production of autoantibodies to RNA antigens, T- and B-cell activation, and pDC activation28. This evidence concerns the gene TLR7 and systemic lupus erythematosus.