To determine the molecular characteristics that are independent of tumor size, a DEG analysis of the four tumor size and SUVmax subgroups identified five shared DEGs (upregulated PSG5, and downregulated TFF3, SOX2, SLC5A5, and SLC5A7) that were related to SUVmax and RFS, and three DEGs (upregulated HOXD10 and downregulated IFNA1 and FER1L6) related to tumor size and RFS that were unrelated to SUVmax. This evidence concerns the gene HOXD10 and neoplasm.