Similarly, tumor-associated NK cells were marked by ZNF683 and KRT81. Tregs in tumors elevated genes with regulatory functions such as RBPJ, CXCR3, and ZBED2 whereas Tregs in normal tissues upregulated CCR7 and CXCR5, indicating distinct mechanisms for immune cell recruitment and infiltration17 (Fig. 2A, B). Here, CXCR5 is linked to neoplasm.