E2F8 and cancer: As for non-immune cell types, cancer cells universally manifested protein serine/threonine kinase activity (PRKCA, GSK3B, and CAMKK2), glycolysis (PLOD1, EGLN3, and P4HA1), mTORC1 signaling (SLC2A1, GMPS, and PDK1), and GO terms associated with the positive regulation of the cell cycle process (E2F7, E2F8, and KIF23; Fig. 2C and Supplementary Fig. S2B).