BRCA and OV patients expressed both AKR1C1 and WNT5A, while normal breast tissues expressed only AKR1C1. Intriguingly, colorectal cancer (CRC) and HNSC patients expressed WNT5A but not AKR1C1 whereas the corresponding normal tissues showed opposite expression patterns (Fig. 4C). This evidence concerns the gene AKR1C1 and colorectal cancer.