The results indicated statistically highly significant differences in most of the body composition parameters: body weight, BMI, waist and hip circumstances, Waist/Height ratio (WHTR), subscapular and abdominal skin fold thickness, central adiposity index, fat percentage, fat mass, free fat mass, water content, BMR (Table 2) and obesity-related biomarkers (Leptin, ALT, and AST) (Table 3) between the pre and post follow up measurements at the end of the study (three-month prebiotic and probiotic intervention); as they were all decreased at the end of the study. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.