Leptin, a hunger-inhibiting hormone secreted mainly by adipocytes and enterocytes42, together with AST enzyme (that may increase because of obesity-associated steatosis43 were the most affected parameters after this current intervention, Leptin being reduced in most of the patients, while AST being reduced in nearly half of the patients. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.