Interestingly, although major macrophage-specific mRNAs (CD68, CD14, and ITGAM) were relatively unchanged, the mRNAs associated with an M2 phenotype (CSFR1, CD163, MS4A4A, and CRC1) were decreased, suggesting a change toward a more M1, anti-tumor status. This evidence concerns the gene MS4A4A and neoplasm.