LYL1 and acute lymphoblastic leukemia: On the other hand, TLX3, HOXA and LYL1/LMO2 had common DNA methylation patterns in cluster M1 and M4, associated with an early immunophenotype (early T-ALL: 17/19 in M1 and M4 vs. 2/19 in M2 and M3, p < 0.0001).