In thymic T-ALL, fewer patients were assigned to the unfavorable subgroups of LYL1/LMO2 (0% 3y-OS, n = 2), TAL1 (55% 3y-OS, n = 12), TLX3 (64% 3y-OS, n = 11) and HOXA (79% 3y-OS, n = 13) compared to mature and early T-ALL. This evidence concerns the gene LYL1 and acute lymphoblastic leukemia.