Nevertheless, targeting IRE1α RNase activity normalized blood glucose concentrations in both BI-1–/– and WT mice fed HFD (Fig. 6B), reduced hyperinsulinemia (Fig. 6C) and pancreatic lipase levels (Fig. 6D), reflecting an improvement in glucose homeostasis and β-cell function. The gene discussed is TMBIM6; the disease is hyperinsulinism.