Thus, we evaluated the potential of treating mice in a regression model: BI-1–/– mice on a 3-month HFD to induce IRE1α RNase activity-dependent ER stress, β-cell dysfunction, and diabetes were treated with an inhibitor of IRE1α RNase activity, STF-083010, twice a week during the last two weeks of diet (Fig. 6A). Here, ERN1 is linked to diabetes mellitus.