PD is characterized by the intracellular accumulation of misfolded \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α-synuclein proteins called Lewy bodies and the subsequent death of midbrain dopaminergic (mDA) neurons in the substantia nigra part of the brain3. The gene discussed is SNCA; the disease is Parkinson disease.