Senescence-like fibroblasts induced by radiation possess fibrotic phenotypes as myofibroblasts, Further study found that FOXO4-DRI can target senescence-like fibroblasts, increase non-small cell lung cancer cells’ radiosensitivity, inhibits the expression of α-SMA and collagen I, these results suggest that blocking p53 significantly reduces radiation-induced pulmonary fibrosis by targeting senescence-like fibroblasts [133]. This evidence concerns the gene TP53 and pulmonary fibrosis.