Similarly, Nomura et al. constructed cardiomyocyte-specific p53 deletion mice and confirmed that p53 activation in cardiomyocytes is critical for the cardiomyocyte senescence and heart failure progression, accompanied by reduced TGF-β signaling-related molecules including TGF-β3, TGF-βR2, and insulin-like growth factor-binding protein-7 (IGFBP7) [115, 116]. This evidence concerns the gene TP53 and heart failure.